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Typical antipsychotic. Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia ). Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions.
The atypical antipsychotics ( AAP ), also known as second generation antipsychotics ( SGAs) and serotonin –dopamine antagonists ( SDAs ), [ 1][ 2] are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely ...
There are two main categories of antipsychotics: typical and atypical. Typical antipsychotics have been around longer and are known as first-generation antipsychotics. Atypical antipsychotics are ...
Placebo-controlled trials of both first- and second-generation antipsychotic drugs consistently demonstrate the superiority of active drugs over placebos in suppressing psychotic symptoms. [25] A large meta-analysis of 38 trials of antipsychotic drugs in schizophrenia with acute psychotic episodes showed an effect size of about 0.5. [35]
Following is a list of antipsychotics, sorted by class. Antipsychotics. Antipsychotics by class Generic name Brand names Chemical class ATC code
The mechanism of actions of most antipsychotics is post-synaptic blockage of brain dopamine D2 receptors. Second generation antipsychotics also bind with serotonin 5HT2 receptors at a high affinity, which is suggested to be the cause for the lowered risk of extrapyramidal side effects compared with first generation antipsychotics. [14]
Aponal, Quitaxon, Sinequan ( doxepin) – a tricyclic antidepressant used to treat nerve pain, insomnia; similar to imipramine. Anquil ( benperidol) – an antipsychotic primarily used to control antisocial hypersexual behaviour. Aricept ( donepezil) – used to slow the progression of Alzheimer's disease. Ativan ( lorazepam) – a ...
Clozapine is a psychiatric medication and was the first atypical antipsychotic (also called second-generation antipsychotic) to be discovered. [6] It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics, or who have been unable to tolerate other drugs due to extrapyramidal side effects.