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Hypoprolactinemia can result from autoimmune disease, [2] hypopituitarism, [1] growth hormone deficiency, [2] hypothyroidism, [2] excessive dopamine action in the tuberoinfundibular pathway and/or the anterior pituitary, and ingestion of drugs that activate the D 2 receptor, such as direct D 2 receptor agonists like bromocriptine and pergolide, and indirect D 2 receptor activators like ...
Prolactin has a wide variety of effects. It stimulates the mammary glands to produce milk (): increased serum concentrations of prolactin during pregnancy cause enlargement of the mammary glands and prepare for milk production, which normally starts when levels of progesterone fall by the end of pregnancy and a suckling stimulus is present.
Meanwhile, breastfeeding quality within the first 48 hours of birth, indicated by signs of successful lactation such as nipple discomfort, is inversely correlated with DOL. [9] This association can be attributed to insufficient nipple stimulation and breast emptying for stimulating lactogenesis II, as a result of low breastfeeding quality. [9]
High levels of prolactin during pregnancy and breastfeeding also increase insulin resistance, increase growth factor levels (IGF-1) and modify lipid metabolism in preparation for breastfeeding. During lactation, prolactin is the main factor maintaining tight junctions of the ductal epithelium and regulating milk production through osmotic balance.
High levels of progesterone, which are associated with pregnancy, inhibits prolactin and therefore lactation. [30] Prolactin increases during the initial stages of lactation and can be stimulated by estrogen but not progesterone. [30] Research, however, focuses on the role of prolactin for breastfeeding and less on other behaviors. [30]
High levels of prolactin are necessary for lactation, however there is no direct correlation between baseline levels of prolactin and quantity of milk production. [5] One aspect of supply regulation that has been identified is that breast milk contains a peptide called feedback inhibitor of lactation (FIL).
Increased levels of prolactin in the paternal brain has also been correlated with a more positive response to the infant's cry. Experienced fathers of newborns show a significantly greater increase in prolactin after hearing their baby's cries or holding their babies than first-time fathers, suggesting that learning is important for males to ...
Male lactation was of some interest to Alexander von Humboldt, who reports in Voyage aux régions équinoxiales du Nouveau Continent about a citizen of the Venezuelan village of Arenas (close to Cumana) who allegedly nurtured his son for three months when his wife was ill, [1] as well as Charles Darwin, who commented on it in The Descent of Man, and Selection in Relation to Sex (1871):