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Free Radical Biology and Medicine is a peer-reviewed scientific journal and official journal of the Society for Redox Biology and Medicine.The journal covers research on redox biology, signaling, biological chemistry and medical implications of free radicals, reactive species, oxidants and antioxidants.
The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. [1] A free radical is any atom or molecule that has a single unpaired electron in an outer shell. [2] While a few free radicals such as melanin are not chemically reactive, most biologically relevant free radicals are highly ...
Free radical mechanisms in tissue injury. Lipid peroxidation induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination). Antioxidants play a crucial role in mitigating lipid peroxidation by neutralizing free radicals, thereby halting radical chain reactions. Key antioxidants include vitamin C and vitamin E. [8]
Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. [1]
The mitochondrial theory of ageing has two varieties: free radical and non-free radical. The first is one of the variants of the free radical theory of ageing. It was formulated by J. Miquel and colleagues in 1980 [1] and was developed in the works of Linnane and coworkers (1989). [2] The second was proposed by A. N. Lobachev in 1978. [3]
Redox Biology is an open-access peer-reviewed scientific journal and an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe. [ 1 ] [ 2 ] The journal covers research on redox biology, aging, signaling, biological chemistry and medical implications of free radicals for health and disease.
Ribbon drawing of the subunit 3D structure of Cu,Zn superoxide dismutase. Irwin Fridovich (August 2, 1929 – November 2, 2019) [1] was an American biochemist who, together with his graduate student Joe M. McCord, discovered the enzymatic activity of copper-zinc superoxide dismutase (SOD), [2] [3] —to protect organisms from the toxic effects of superoxide free radicals formed as a byproduct ...
Rafael Radi is a Uruguayan biochemist and biomedical scientist who has extensively worked to elucidate molecular mechanisms by which free radicals, oxidants and nitric oxide participate in human pathologies. In particular, he has made relevant contributions to unravelling how the signal transducing free radical nitric oxide can evolve into ...