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Dobutamine is a direct-acting agent whose primary activity results from stimulation of the β 1-adrenoceptors of the heart, increasing contractility and cardiac output. Since it does not act on dopamine receptors to inhibit the release of norepinephrine (another α 1 agonist), dobutamine is less prone to induce hypertension than is dopamine.
General indications ... [10] [11] Nausea [10] [11] ... dobutamine selectively binds to β1 receptors located on the surface of specialised cardiac muscle cells. ...
Most agonists of the beta receptors are selective for one or more beta-adrenoreceptors. For example, patients with low heart rate are given beta agonist treatments that are more "cardio-selective" such as dobutamine, which increases the force of contraction of the heart muscle.
The mechanisms of sympathomimetic drugs can be direct-acting (direct interaction between drug and receptor), such as α-adrenergic agonists, β-adrenergic agonists, and dopaminergic agonists; or indirect-acting (interaction not between drug and receptor), such as MAOIs, COMT inhibitors, release stimulants, and reuptake inhibitors that increase the levels of endogenous catecholamines.
Indications for termination: A cardiac stress test should be terminated before completion under the following circumstances: [33] [34] Absolute indications for termination include: Systolic blood pressure decreases by more than 10 mmHg with increase in work rate, or drops below baseline in the same position, with other evidence of ischemia.
A Michigan doctor and his wife are accused of locking their 10-year-old son with special needs in a closet for hours a day over several months, at times forcing him to clean his own feces.. It's ...
Very common (greater than 10%) adverse effects include fast heart beats and nausea. [2] Common (between 1% and 10%) adverse effects include tremor, headache, transient low blood pressure, vomiting, increased sweating, sepsis, sinus and nodal slow heart beat, cardiac arrest, myocardial infarction, cardiac enzyme changes, non-specific ECG changes, high blood pressure, hemorrhage, respiratory ...
10/1 ARM. 10 years. Once per year. Rate locked for 10 years, then adjusts every 12 months. 3/6 ARM. 3 years. ... If economic indicators suggest interest rates will keep declining, staying with ...