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A new study is raising fresh questions about the value of breast cancer screening in older women, finding that those 70 and older who underwent mammograms were more apt to be diagnosed with tumors ...
Breast cancer predominantly affects women; less than 1% of those with breast cancer are men. [153] Women can develop breast cancer as early as adolescence, but risk increases with age, and 75% of cases are in women over 50 years old. [153] The risk over a woman's lifetime is approximately 1.5% at age 40, 3% at age 50, and more than 4% risk at ...
[3] [4] It is also the most common form of breast cancer occurring in men, accounting for 85% of cases. [5] [6] The incidence of ductal carcinomas as a whole is 86.3 cases per 100,000 women, with the incidence increasing sharply for women over 40 years of age and peaking at 285.6 cases per 100,000 for women between 70 and 79.
Nearly half of women over 40 have dense breasts, which bring an elevated risk of breast cancer and also tend to mask it in screenings. Women will now be notified about breast density after mammograms.
The Annals study estimated that significant numbers of women over 70 are potentially overdiagnosed for breast cancer, including nearly half of those aged 75 to 84.
Staging breast cancer is the initial step to help physicians determine the most appropriate course of treatment. As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system.
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