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CD25 deficiency or interleukin 2 receptor alpha deficiency is an immunodeficiency disorder associated with mutations in the interleukin 2 receptor alpha (CD25) (IL2RA) gene. The mutations cause expression of a defective α chain or complete absence thereof, an essential part of high-affinity interleukin-2 (IL-2) receptors.
Homodimeric alpha chains (IL2RA) result in low-affinity receptor (Kd ~10−8M) with no signalling ability, while dimeric beta and gamma chains produce a medium-affinity receptor (Kd ~10−9M). Moreover, CD25 is an exclusive subunit that entirely binds IL-2, while CD132 binds the shared γc family cytokines (IL-4, IL-7, IL-9, IL-15 and IL-21 ...
IL-2 binds to the IL-2 receptor, which has three forms, generated by different combinations of three different proteins, often referred to as "chains": α (alpha) (also called IL-2Rα, CD25, or Tac antigen), β (beta) (also called IL-2Rβ, or CD122), and γ (gamma) (also called IL-2Rγ, γ c, common gamma chain, or CD132); these subunits are also parts of receptors for other cytokines.
Board Established City Website Refs Catholic Board of Education, Pakistan: 1961 Karachi [47] Lahore [48] [49] Diocesan board of education, Pakistan 1960 Islamabad, Rawalpindi [50] [51] Presbyterian Education Board Pakistan Lahore, Punjab
The FBISE was established under the FBISE Act 1975. [2] It is an autonomous body of working under the Ministry of Federal Education and Professional Training. [3] The official website of FBISE was launched on June 7, 2001, and was inaugurated by Mrs. Zobaida Jalal, the Minister for Education [4] The first-ever online result of FBISE was announced on 18 August 2001. [5]
The Board of Secondary Education, Karachi is a government board in Karachi for secondary education examination. It was established in 1950 by the promulgation of the Central Legislative Act No. XVI of 1950. [1] BSEK controls and organizes the secondary education examinations in Karachi.
The re-construction of the Board of Intermediate and Secondary Education, Lahore has been done through the Punjab Boards of Intermediate and Secondary Education Act 1976 (lately amended by Punjab Ordinance No.XLVII). Currently, nine Boards are functioning in the Punjab province at division level.
Cytokine receptor common subunit gamma also known as interleukin-2 receptor subunit gamma or IL-2RG is a protein that in humans is encoded by the IL2RG gene. [8] The human IL2RG gene is located on the long (q) arm of the X chromosome at position 13.1, from base pair 70,110,279 to base pair 70,114,423.