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Drugs like Gabapentin, Trazodone, or Alpha-2 Agonists can be used alone to produce these effects. [3] The second level is light sedation, where the patient is slightly under for a short period of time. Examples of anesthetics to achieve this level are opioids and benzodiazepine. In cats, opioids alone are used to produce this effect.
It is less effective as a sedative if the horse is already excited. [23] Additionally, acepromazine is used as a vasodilator in the treatment of laminitis, where an oral dose equivalent to "mild sedation" is commonly used, although the dose used is highly dependent on the treating veterinarian. While it is shown to elicit vasodilation in the ...
Gabapentin acts by decreasing activity of a subset of calcium channels. [13] [14] [15] Gabapentin was first approved for use in 1993. [16] It has been available as a generic medication in the United States since 2004. [17] In 2022, it was the tenth most commonly prescribed medication in the United States, with more than 40 million prescriptions.
Alfaxalone is used as an induction agent, an injectable anesthetic, and a sedative in animals. [5] While it is commonly used in cats and dogs, it has also been successfully used in rabbits, [6] horses, sheep, pigs, and exotics such as red-eared turtles, axolotl, green iguanas, marmosets, [7] and koi fish. [8]
prednisolone – glucocorticoid (steroid) used in the management of inflammation and auto-immune disease, primarily in cats; prednisone – glucocorticoid (steroid) used in the management of inflammation and auto immune disease; pregabalin – neuropathic pain reliever and anti-convulsant; propofol – short acting intravenous drug used to ...
Unlike gabapentin, which is transported solely by the LAT1, [104] [12] pregabalin seems to be transported not only by the LAT1 but also by other carriers. [26] The LAT1 is easily saturable, so the pharmacokinetics of gabapentin are dose-dependent, with diminished bioavailability and delayed peak levels at higher doses. [26]
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