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Once it is there, it is added to the growing glycan chain by the enzyme peptidoglycan glycosyltransferase (GTase, EC 2.4.1.129). This reaction is known as transglycosylation. In the reaction, the hydroxyl group of the GlcNAc will attach to the MurNAc in the glycan, which will displace the lipid-PP from the glycan chain. [20]
PG is finally synthesized when a PGP phosphatase enzyme catalyzes the immediate dephosphorylation of the PGP intermediate to form PG. [4] In bacteria, another membrane phospholipid known as cardiolipin can be synthesized by condensing two molecules of phosphatidylglycerol; a reaction catalyzed by the enzyme cardiolipin-synthase. [ 5 ]
Propylene glycol (IUPAC name: propane-1,2-diol) is a viscous, colorless liquid.It is almost odorless and has a faintly sweet taste. Its chemical formula is CH 3 CH(OH)CH 2 OH. . As it contains two alcohol groups, it is classified as a d
Prostaglandins (PG) are a group of physiologically active lipid compounds called eicosanoids [1] that have diverse hormone-like effects in animals. Prostaglandins have been found in almost every tissue in humans and other animals.
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The prostacyclin receptor, also termed the prostaglandin I 2 receptor or just IP, is a receptor belonging to the prostaglandin (PG) group of receptors. IP binds to and mediates the biological actions of prostacyclin (also termed prostaglandin I 2, PGI 2, or when used as a drug, epoprostenol). IP is encoded in humans by the PTGIR gene.
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Perhaps the different acyl chains can affect the angle of the head-group in the membrane. If this is the case, it suggests that a PA-binding domain must not only be able to bind PA specifically but must also be able to identify those head-groups that are at the correct angle. Whatever the mechanism is, such specificity is possible.