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The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action (pharmacokinetics). [1] The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry, and system dynamics.
However, if a delay is observed between the drug administration and the drug effect, a temporal dissociation needs to be taken into account and more complex models exist: [6] [7] Direct vs Indirect link PK/PD models; Direct vs Indirect response PK/PD models [8] Time variant vs time invariant; Cell lifespan models; Complex response models
The University of Texas Southwestern Medical Center (UT Southwestern or UTSW) is a public academic health science center in Dallas, Texas.With approximately 23,000 employees, [3] more than 3,000 full-time faculty, and nearly 4 million outpatient visits per year, UT Southwestern is the largest medical school in the University of Texas System and the State of Texas.
The IUPHAR/BPS Guide to PHARMACOLOGY is an open-access website, acting as a portal to information on the biological targets of licensed drugs and other small molecules. The Guide to PHARMACOLOGY (with GtoPdb being the standard abbreviation) is developed as a joint venture between the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS).
Biopharmacology – the pharmacology of biopharmaceuticals; Clinical pharmacology – the scientific discipline focused on rational drug development and utilization in therapeutics; Pharmacokinetics – the study of the fate of drugs administered to the body Bioequivalence – the biological equivalence of two preparations of a drug
Drug-drug interactions can occur when certain drugs are administered at the same time. Effects of this can be additive (outcome is greater than those of one individual drug), less than additive (therapeutic effects are less than those of one individual drug), or functional alterations (one drug changes how another is absorbed, distributed, and ...
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The main aim of clinical pharmacology is to generate data for optimum use of drugs and the practice of 'evidence-based medicine'. Clinical pharmacologists have medical and scientific training that enables them to evaluate evidence and produce new data through well-designed studies .
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