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The diagnosis is made by the clinical picture and the chest X-ray, which demonstrates decreased lung volumes (bell-shaped chest), absence of the thymus (after about six hours), a small (0.5–1 mm), discrete, uniform infiltrate (sometimes described as a "ground glass" appearance or "diffuse airspace and interstitial opacities") that involves ...
When these are subjected to immunofluorescence, three patterns can be observed: linear, granular and negative (pauci-immune). [1] The linear and granular patterns are examples of positive immunofluorescence that are associated as follows: Goodpasture syndrome (linear pattern), post-streptococcal glomerulonephritis (granular), and diffuse ...
Diffuse alveolar damage (DAD) is a histologic term used to describe specific changes that occur to the structure of the lungs during injury or disease. Most often DAD is described in association with the early stages of acute respiratory distress syndrome ( ARDS ). [ 1 ]
Lung washings characteristically yield a fluid which is "milky"composition. Under the microscope, samples show 20-50 micrometer PAS-positive globules on a background of finely granular or amorphous PAS-positive material. There is typically a low numbers of macrophages and inflammatory cells (although this is variable). [14] [15]
America's Blood Centers (ABC), North America's largest network of non-profit community blood centers. [2] Most of the independent blood centers on this list are ABC members, and these account for approximately 60 percent of the U.S. blood supply. [3] Blood Centers of America (BCA), a national cooperative of independent blood centers. [4]
Ground-glass opacity is in contrast to consolidation, in which the pulmonary vascular markings are obscured. [3] [5] GGO can be used to describe both focal and diffuse areas of increased density. [5] Subtypes of GGOs include diffuse, nodular, centrilobular, mosaic, crazy paving, halo sign, and reversed halo sign. [6]
The liquid can be pulmonary edema, inflammatory exudate, pus, inhaled water, or blood (from bronchial tree or hemorrhage from a pulmonary artery). Consolidation must be present to diagnose pneumonia: the signs of lobar pneumonia are characteristic and clinically referred to as consolidation. [3]
Howell was the first to describe these blood cells as being of the prototype stippling, which meant granular degeneration of the red blood cells. [7] In 1893, Max Askanazy, who was studying the blood of an anemic patient, discovered granulation in the blood cells that were polychromatic. Later studies were done by other scientists also showed ...