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Brugada syndrome has been described as overlapping with arrhythmogenic right ventricular cardiomyopathy (ARVC) caused by a mutation in the PKP2 gene, causing a Brugada ECG pattern but structural changes in the heart characteristic of ARVC. [27]
Recently described syndromes such as the Brugada Syndrome may give clues to the underlying mechanism of ventricular arrhythmias. In the Brugada syndrome, changes may be found in the resting ECG with evidence of right bundle branch block (RBBB) and ST elevation in the chest leads V1–V3, with an underlying propensity to sudden cardiac death. [10]
ECG pattern in Brugada syndrome. According to recent consensus document (ref 13), type 1 ST segment elevation either spontaneously present or induced with Ajmaline/Flecainide test is considered diagnostic. Type 1 and 2 may lead to suspicion but drug challenge is required for diagnosis.
A type of a deadly ventricular arrhythmia - Ventricular fibrillation pattern seen on an ECG: Specialty: Cardiology Causes: Ion channelopathies: Long QT syndrome (LQTS), Brugada syndrome, CPVT (catecholaminergic polymorphic ventricular tachycardia), PCCD (progressive cardiac conduction defect), Early repolarization syndrome, Mixed sodium channel ...
Long QT syndrome is estimated to affect 1 in 7,000 people. [6] Females are affected more often than males. [6] Most people with the condition develop symptoms before they are 40 years old. [6] It is a relatively common cause of sudden death along with Brugada syndrome and arrhythmogenic right ventricular dysplasia. [3]
Changes in the normal ECG pattern occur in numerous cardiac abnormalities, including: Cardiac rhythm disturbances, such as atrial fibrillation [6] and ventricular tachycardia; [7] Inadequate coronary artery blood flow, such as myocardial ischemia [8] and myocardial infarction; [9] and electrolyte disturbances, such as hypokalemia. [10]
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Brugada syndrome is typically diagnosed using an electrocardiogram (ECG), although medications such as ajmaline may be required to produce the characteristic ECG pattern. [1] There is no cure for Brugada syndrome, but the condition may be treated using an implantable cardioverter defibrillator (ICD). [3]