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Amitriptyline is probably effective for the prevention of periodic migraine in adults. Amitriptyline is similar in efficacy to venlafaxine and topiramate but carries a higher burden of adverse effects than topiramate. [16] For many patients, even very small doses of amitriptyline are helpful, which may allow for minimization of side effects. [38]
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Elavil (amitriptyline) – a tricyclic antidepressant used as a first-line treatment for neuropathic pain; Eurodin, Prosom – a benzodiazepine derivative with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties, commonly prescribed for short-term treatment of insomnia
Amitriptyline Nortriptyline (Amitriptyline's active metabolite) Perphenazine Notes SERT: 3.13: 16.5? It is this and its NET-inhibiting action is believed to give amitriptyline its antidepressant action. NET: 22.4: 4.37? See above. DAT: 5380: 3100? 5-HT 1A: 450: 294: 421: Binding for human brain receptors had to be substituted in amitriptyline ...
Previous systematic reviews and meta-analyses had not comprehensively assessed TCAs in the same fashion, with the largest including only two TCAs (amitriptyline and clomipramine) and only 36 trials. [ 11 ] [ 12 ] A total of 103 short-term clinical trials with 10,590 participants employing 12 different TCAs (and TeCAs) were included. [ 11 ]
ATC code N06 Psychoanaleptics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
The peripheral autonomic nervous system, central nervous system and the heart are the main systems that are affected following overdose. [1] Initial or mild symptoms typically develop within 2 hours and include tachycardia, drowsiness, a dry mouth, nausea and vomiting, urinary retention, confusion, agitation, and headache. [7]
YouTube is an American social media and online video sharing platform owned by Google. YouTube was founded on February 14, 2005, by Steve Chen, Chad Hurley, and Jawed Karim, three former employees of PayPal. Headquartered in San Bruno, California, it is the second-most-visited website in the world, after Google Search.