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8888, also known as the Citizens ' Complaint Hotline and the President's Hotline, is a 24/7 national public service hotline operated by the government of the Philippines.It was introduced on August 1, 2016, by President Rodrigo Duterte to allow the public to report poor government front-line service delivery and corrupt practices in all government agencies, government-owned and controlled ...
BIR domains belong to the zinc-finger domain family and characteristically have a number of invariant amino acid residues, including 3 conserved cysteines and one conserved histidine, which coordinate a zinc ion. [4] They are typically composed of 4-5 alpha helices and a three-stranded beta sheet.
MAPKs are involved in directing cellular responses to a diverse array os stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines regulating cell functions including proliferation, gene expression, differentiation, mitosis, cell survival or apoptosis. [13] cIAP1 is as well implicated in innate immunity.
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XIAP has been characterized with three amino-terminal BIR domains followed by one UBA domain and finally one RING domain. [9] Between the BIR-1 and BIR-2 domains, there is a linker-BIR-2 region that is thought to contain the only element that comes into contact with the caspase molecule to form the XIAP/Caspase-7 complex. [10]