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The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants, OX 1 and OX 2 , each encoded by a different gene ( HCRTR1 , HCRTR2 ).
The orexin 1 receptor (OX 1), is a G-protein coupled receptor that is heavily expressed in projections from the lateral hypothalamus and is involved in the regulation of feeding behaviour. OX 1 selectively binds the orexin-A neuropeptide. It shares 64% identity with OX 2. [5]
The orexin peptides bind to the two G-protein coupled orexin receptors, OX 1 and OX 2, with orexin-A binding to both OX 1 and OX 2 with approximately equal affinity while orexin-B binds mainly to OX 2 and is 5 times less potent at OX 1. [20] [21] The orexins are strongly conserved peptides, found in all major classes of vertebrates. [22]
Orexin receptor type 2 (Ox2R or OX 2), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene. [5] It should not be confused for the protein CD200R1 which shares the alias OX2R but is a distinct, unrelated gene located on the human chromosome 3.
Once made, the orexin peptides can bind to the orexin receptor; which is a G protein-coupled receptor. This receptor senses molecules outside the cell and activates inside signal transduction pathways to elicit cellular responses. Research shows that an absence of orexin-A appears to cause narcolepsy. Deficit amounts of orexin-A will make ...
Pages in category "G protein-coupled receptors" The following 200 pages are in this category, out of approximately 385 total. ... Hypocretin (orexin) receptor 2; I.
The salad lasts the entire week, she said, and "it's basically the only thing that ensures I get enough protein and vegetables throughout the week." Original article source: Top five most searched ...
The seven-transmembrane α-helix structure of bovine rhodopsin. G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and ...
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