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Mutations to homeobox genes can produce easily visible phenotypic changes in body segment identity, such as the Antennapedia and Bithorax mutant phenotypes in Drosophila. Duplication of homeobox genes can produce new body segments, and such duplications are likely to have been important in the evolution of segmented animals.
n/a Ensembl ENSG00000185960 n/a UniProt O15266 n/a RefSeq (mRNA) n/a n/a RefSeq (protein) NP_000442 NP_006874 n/a Location (UCSC) n/a n/a PubMed search n/a Wikidata View/Edit Human The short-stature homeobox gene (SHOX), also known as short-stature-homeobox-containing gene, is a gene located on both the X and Y chromosomes, which is associated with short stature in humans if mutated or present ...
Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. The CDX-2 protein is a homeobox transcription factor expressed in the nuclei of intestinal epithelial cells, [5] [6] playing an essential role in the development and function of the digestive system. CDX2 is part of the ParaHox gene cluster, a group of three highly ...
Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [6] Msx2 is a homeobox gene localized on human chromosome 5 that encodes a transcription repressor and activator (MSX-2) responsible for craniofacial and limb-bud development. Cells will express msx2 when exposed to signaling molecules BMP-2 and BMP-4 in ...
Zinc finger E-box-binding homeobox 2 is a protein that in humans is encoded by the ZEB2 gene. [5] The ZEB2 protein is a transcription factor that plays a role in the transforming growth factor β (TGFβ) signaling pathways that are essential during early fetal development.
This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues.
The homeobox gene clusters studied by Ed Lewis were named the Hox genes, although many more homeobox genes are encoded by animal genomes than those in the Hox gene clusters. The homeotic-function of certain proteins was first postulated to be that of a "selector" as proposed by Antonio Garcia-Bellido . [ 11 ]
15430 Ensembl ENSG00000128710 ENSMUSG00000050368 UniProt P28358 P28359 RefSeq (mRNA) NM_002148 NM_013554 RefSeq (protein) NP_002139 NP_038582 Location (UCSC) Chr 2: 176.11 – 176.12 Mb Chr 2: 74.52 – 74.53 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene. Function This gene is a member of ...