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The formation of phenyl-hydroxy bromazolam was catalysed by CYP2B6, CYP2C19, and CYP3A4. 4-hydroxy bromazolam, as well as α-hydroxy bromazolam, were formed by CYP2B6, CYP2C19, CYP3A4, and CYP3A5. Additionally, CYP2C9 was found to catalyse the formation of α-hydroxy bromazolam as well. α-4-dihydroxy bromazolam was only found in incubations ...
An assortment of several designer drugs. Designer drugs are structural or functional analogues of controlled substances that are designed to mimic the pharmacological effects of the parent drug while avoiding detection or classification as illegal.
The tables below contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics, such as half-life and equivalent doses to other benzodiazepines, also listed, along with their trade names and primary uses.
Phenazolam, (Clobromazolam, DM-II-90, BRN 4550445) is a benzodiazepine derivative which acts as a potent sedative and hypnotic drug. It was first invented in the early 1980s, [1] but was never developed for medical use.
Deamination of desmethyladinazolam leads to the formation of an intermediate metabolite, which undergoes alpha-hydroxylation to form alpha-hydroxy-alprazolam or cleavage of side chain to form estazolam, which are minor metabolites. [2] [24] [26] [27] [6] [17] [28] The metabolism of adinazolam and its metabolites.
The following drugs are controlled by the German Narcotic Drugs Act (German: Betäubungsmittelgesetz or BtMG). Trade and possession of these substances without licence or prescription is considered illegal; prescription is illegal for drugs on Anlage I and II and drugs on Anlage III require a special prescription form.
It is an intermediate in the redox-related pair C 6 H 5 NH 2 and C 6 H 5 NO. N -Phenylhydroxylamine should not be confused with its isomer α-phenylhydroxylamine or O -phenylhydroxylamine. Preparation
[2] [3] It is closely related to clonazolam or flunitrazolam , only differing by the removal of a chlorine or fluorine group respectively at the benzene ring. A study in mice indicated that nitrazolam can be several times more potent than diazepam as an antagonist of electroshock-induced tonic-extensor convulsions but less potent than diazepam ...