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Unlike the GnRH agonists, which cause an initial stimulation of the hypothalamic–pituitary–gonadal axis (HPG axis) that leads to a surge in testosterone or estrogen levels, GnRH antagonists have an immediate onset of action and rapidly reduce sex hormone levels without an initial surge.
Leuprorelin, also known as leuprolide, is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, for early puberty, or as part of transgender hormone therapy. [10] [11] It is given by injection into a muscle or under the skin. [10]
Desogestrel is a hormone blocker, progesterone receptors agonist, and antiandrogen.It is used in conjunction with estrogens and testosterones.Medications containing desogestrel and estrogen are used to treat endometriosis [21] [29] and as a component of menopausal hormone therapy.
Because danazol reduces estrogen production and levels, [38] it has functional antiestrogenic properties. [41] The combination of its antiestrogenic, androgenic, and progestogenic or antiprogestogenic actions cause atrophy of the endometrium, which alleviates the symptoms of endometriosis. [4] [5] [16] [38] [42]
Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) and works by preventing the production of sex hormones by the gonads. [1] [2] It can lower sex hormone levels by 95% in both sexes. [1] [2] Nafarelin is a peptide and an analogue of GnRH Tooltip gonadotropin-releasing hormone. [8] Nafarelin was introduced for medical use in 1990.
Treatment for both cancers can include surgery, chemotherapy, radiation and hormone blockers, which are also used in hormone positive breast cancers. Recently the FDA approved a new immunotherapy ...
It found that less than 0.1% of U.S. transgender and gender diverse (TGD) adolescents were prescribed puberty blockers or gender-affirming hormones—and that not a single patient under age 12 ...
Buserelin, sold under the brand name Suprefact among others, is a medication which is used primarily in the treatment of prostate cancer and endometriosis. [3] [1] [2] It is also used for other indications such as the treatment of premenopausal breast cancer, uterine fibroids, and early puberty, in assisted reproduction for female infertility, and as a part of transgender hormone therapy.