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Tiotropium was patented in 1989, and approved for medical use in 2002. [12] It is on the World Health Organization's List of Essential Medicines. [13] In 2022, it was the 154th most commonly prescribed medication in the United States, with more than 3 million prescriptions. [14] [15]
One study of a dog suffering from a toxic dose found that it was probably 111 milligrams per kilogram, or about 100 times the normal dose (3). Other reports list the lethal dose (LD50) at 24 to 30 ...
The median lethal dose of theobromine for dogs is 100–200 mg/kg (0.0016–0.0032 oz/lb); therefore, a 10 kg (22 lb) dog would need to consume a minimum of 200 g (7.1 oz) of the most theobromine-rich (5 g/kg (0.080 oz/lb)) dark chocolate, or a maximum of 1 kg (2.2 lb) (of theobromine-rich milk chocolate), to have a 50% chance of receiving a ...
Senior dogs may need to urinate four to six times a day due to aging or health conditions affecting bladder control. You might want to read our guide on how to stop your dog peeing around the house .
For example, 0.4 oz (11 g) of baker's chocolate would be enough to produce mild symptoms in a 20 lb (9.1 kg) dog, while a 25% cacao chocolate bar (like milk chocolate) would be only 25% as toxic as the same dose of baker's chocolate. [15] One ounce of milk chocolate per pound of body weight (63 g/kg) is a potentially lethal dose in dogs. [14]
Additionally, dogs have much larger olfactory mucosa and a larger part of the brain dedicated to odors. Whereas in humans, 5% of the brain is dedicated to odors, in dogs this figure is 33%. Dogs are able to detect odors 9 orders of magnitude more faint than humans, who can detect odors up to 1 ppb .
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261