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3D still showing rabies virus structure. Rhabdoviruses have helical symmetry, so their infectious particles are approximately cylindrical in shape. They are characterized by an extremely broad host spectrum ranging from plants [citation needed] to insects [citation needed] and mammals; human-infecting viruses more commonly have icosahedral symmetry and take shapes approximating regular polyhedra.
Lyssavirus (from the Greek λύσσα lyssa "rage, fury, rabies" and the Latin vīrus) [1][2] is a genus of RNA viruses in the family Rhabdoviridae, order Mononegavirales. Mammals, including humans, can serve as natural hosts. [3][4] The genus Lyssavirus includes the causative agent (rabies virus) of rabies. [5]
Rabies is caused by a number of lyssaviruses including the rabies virus and Australian bat lyssavirus. [4] Duvenhage lyssavirus may cause a rabies-like infection. [33] The rabies virus is the type species of the Lyssavirus genus, in the family Rhabdoviridae, order Mononegavirales.
Retrograde tracing is a research method used in neuroscience to trace neural connections from their point of termination (the synapse) to their source (the cell body). Retrograde tracing techniques allow for detailed assessment of neuronal connections between a target population of neurons and their inputs throughout the nervous system.
The lytic cycle (/ ˈlɪtɪk / LIT-ik) is one of the two cycles of viral reproduction (referring to bacterial viruses or bacteriophages), the other being the lysogenic cycle. The lytic cycle results in the destruction of the infected cell and its membrane. Bacteriophages that can only go through the lytic cycle are called virulent phages (in ...
Animals with "dumb" rabies appear depressed, lethargic, and uncoordinated. Gradually they become completely paralyzed. When their throat and jaw muscles are paralyzed, the animals will drool and have difficulty swallowing. In animals, rabies is a viral zoonotic neuro-invasive disease which causes inflammation in the brain and is usually fatal.
Viral envelope. A viral envelope is the outermost layer of many types of viruses. [1] It protects the genetic material in their life cycle when traveling between host cells. Not all viruses have envelopes. A viral envelope protein or E protein is a protein in the envelope, which may be acquired by the capsid from an infected host cell.
Negri bodies are eosinophilic, sharply outlined, pathognomonic inclusion bodies (2–10 μm in diameter) found in the cytoplasm of certain nerve cells containing the virus of rabies, especially in pyramidal cells [1] within Ammon's horn of the hippocampus. They are also often found in the Purkinje cells [1] of the cerebellar cortex from ...