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The tetranucleotide hypothesis of Phoebus Levene [1] proposed that DNA was composed of repeating sequences of four nucleotides. [2] It was very influential for three decades, and was developed by Levene at least into the 1910, and the diagram at the right illustrates the view of Levene and Tipson. [3] In 1940, at the time of Levene's death ...
Levene published over 700 original papers and articles on biochemical structures. Levene died in 1940, before the true significance of DNA became clear. Levene is known for his tetranucleotide hypothesis [7] which proposed that DNA was made up of equal amounts of adenine, guanine, cytosine, and thymine
Phoebus Levene's influential "tetranucleotide hypothesis", which incorrectly proposed that DNA was a repeating set of identical nucleotides, supported this conclusion.
According to Phoebus Levene's influential "tetranucleotide hypothesis", DNA consisted of repeating units of the four nucleotide bases and had little biological specificity. DNA was therefore thought to be the structural component of chromosomes , whereas the genes were thought likely to be made of the protein component of chromosomes.
For this research, Chargaff is credited with disproving the tetranucleotide hypothesis [14] (Phoebus Levene's widely accepted hypothesis that DNA was composed of a large number of repeats of GACT). Most researchers had previously assumed that deviations from equimolar base ratios (G = A = C = T) were due to experimental error, but Chargaff ...
[191] [192] [193] In 1929, Levene identified deoxyribose sugar in "thymus nucleic acid" (DNA). [194] Levene suggested that DNA consisted of a string of four nucleotide units linked together through the phosphate groups ("tetranucleotide hypothesis"). Levene thought the chain was short and the bases repeated in a fixed order.
Levene's test. In statistics, Levene's test is an inferential statistic used to assess the equality of variances for a variable calculated for two or more groups. [1] This test is used because some common statistical procedures assume that variances of the populations from which different samples are drawn are equal.
Deoxyribose, or more precisely 2-deoxyribose, is a monosaccharide with idealized formula H− (C=O)− (CH 2)− (CHOH) 3 −H. Its name indicates that it is a deoxy sugar, meaning that it is derived from the sugar ribose by loss of a hydroxy group. Discovered in 1929 by Phoebus Levene, [2] deoxyribose is most notable for its presence in DNA.