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Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C 5 H 4 N 4 O 3.It forms ions and salts known as urates and acid urates, such as ammonium acid urate.
By decreasing plasma uric acid levels, help dissolve these crystals, while limiting the formation of new ones. However, the increased uric acid levels in urine can contribute to kidney stones . Thus, use of these drugs is contraindicated in persons already with a high urine concentration of uric acid ( hyperuricosuria ).
Hyperuricaemia or hyperuricemia is an abnormally high level of uric acid in the blood.In the pH conditions of body fluid, uric acid exists largely as urate, the ion form. [1] [2] Serum uric acid concentrations greater than 6 mg/dL for females, 7 mg/dL for males, and 5.5 mg/dL for youth (under 18 years old) are defined as hyperuricemia. [3]
Allopurinol is used to reduce urate formation in conditions where urate deposition has already occurred or is predictable. The specific diseases and conditions where it is used include gouty arthritis, skin tophi, kidney stones, idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate ...
Foods that reduce inflammation include fatty fish, tea, walnuts, and more. Here, a dietitian explains the best anti-inflammatory foods to eat. A Dietitian’s Take on Foods That Fight Inflammation
Pegloticase is given as an intravenous infusion every two weeks, [6] and has been found to reduce uric acid levels in this population. [7] There is moderate quality evidence that It is useful for tophi but has a high rate of side effects and withdrawals due to adverse events. [8] About 40% of people develop resistance to the medication over ...
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It is a recombinant version of urate oxidase, an enzyme that metabolizes uric acid to allantoin. Urate oxidase is known to be present in many mammals but does not naturally occur in humans. [ 3 ] Rasburicase is produced by a genetically modified Saccharomyces cerevisiae strain.
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