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Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...
Ann and Robert H. Lurie Children's Hospital of Chicago: Chicago: Illinois 360 Level I Pediatric [5] 3 10 The Children's Hospital of Illinois: Peoria: Illinois 144 Level I Pediatric [5] 3 1 La Rabida Children's Hospital: Chicago Illinois 30 Rush University Children's Hospital: Chicago Illinois 115 3 St. John's Children's Hospital Springfield ...
Nausea, vomiting, and diarrhea (especially at higher doses) Prolonged cardiac QT interval (especially erythromycin) Hearing loss (especially at higher doses) Jaundice; Inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, thereby inhibiting translocation of peptidyl tRNA. Clarithromycin ...
Vancomycin is recommended to be administered in a dilute solution slowly, over at least 60 min (maximum rate of 10 mg/min for doses >500 mg) [21] due to the high incidence of pain and thrombophlebitis and to avoid an infusion reaction known as vancomycin flushing reaction. This phenomenon has been often clinically referred to as "red man syndrome".
Glycopeptide antibiotics are a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic nonribosomal peptides.Significant glycopeptide antibiotics include the anti-infective antibiotics vancomycin, teicoplanin, telavancin, ramoplanin, avoparcin and decaplanin, corbomycin, complestatin and the antitumor antibiotic bleomycin.
[5] [19] The Essential Medicines List (EML) was updated in July 2023 to its 23rd edition. This list contains 1200 recommendations for 591 drugs and 103 therapeutic equivalents. [20] A separate list for children up to 12 years of age, known as the WHO Model List of Essential Medicines for Children (EMLc), was created in 2007 and is in its 9th ...
An example for a simple case (mono-compartmental) would be to administer D=8 mg/kg to a human. A human has a blood volume of around V b l o o d = {\displaystyle V_{blood}=} 0.08 L/kg . [ 7 ] This gives a C 0 = {\displaystyle C_{0}=} 100 μg/mL if the drug stays in the blood stream only, and thus its volume of distribution is the same as V b l o ...
UCSF Benioff Children's Hospital: Oakland: California: 183: I Valley Children's Hospital: Madera: California: 358: II Ventura County Medical Center: Ventura: California: 208: II Zuckerberg San Francisco General Hospital and Trauma Center: San Francisco: California: 397 I Children's Hospital Colorado: Aurora: Colorado: 434 I Denver Health ...