Search results
Results from the WOW.Com Content Network
Epithelial–mesenchymal transition was first recognized as a feature of embryogenesis by Betty Hay in the 1980s. [ 1 ] [ 2 ] EMT, and its reverse process, MET ( mesenchymal-epithelial transition ) are critical for development of many tissues and organs in the developing embryo, and numerous embryonic events such as gastrulation , neural crest ...
Unlike epithelial cells – which are stationary and characterized by an apico-basal polarity with binding by a basal lamina, tight junctions, gap junctions, adherent junctions and expression of cell-cell adhesion markers such as E-cadherin, [4] mesenchymal cells do not make mature cell-cell contacts, can invade through the extracellular matrix, and express markers such as vimentin ...
Neural mesenchyme soon undergoes a mesenchymal–epithelial transition under the influence of WNT6 produced by ectoderm to form somites. [20] These structures will undergo a secondary EMT as the somite tissue migrates later in development to form structural connective tissue such as cartilage and skeletal muscle. [21]
Wnt signaling is involved in another key migration process known as the epithelial-mesenchymal transition (EMT). This process allows epithelial cells to transform into mesenchymal cells so that they are no longer held in place at the laminin. It involves cadherin down-regulation so that cells can detach from laminin and migrate.
For example, cancer cells undergo epithelial to mesenchymal transition (EMT) that plays important roles in their survival, proliferation, and development of resistance to therapeutic treatments, [2] [3] or switch to a phenotype that mimics stem cell-like features – the so-called Cancer Stem Cells (CSCs) or Tumour-initiating Cells.
The stem cells in ERM can undergo an epithelial–mesenchymal transition and differentiate into diverse types of cells of mesodermal and ectodermal origin like bone, fat, cartilage and neuron-like cells. [2]
As other trophoblast subtypes in the placental are epithelial, mesenchymal markers like vimentin and fibronectin can also be used for identification. These markers, however, are not specific to EVT and can also stain stromal cells in the placenta. [13] As trophoblasts develop, they express different integrins.
AV epithelial-mesenchymal transition (EMT) Notch signaling is also important for the process of AV EMT , which is required for AV canal maturation. After the AV canal boundary formation, a subset of endocardial cells lining the AV canal are activated by signals emanating from the myocardium and by interendocardial signaling pathways to undergo ...