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An oxazolidinone derivative used for other purposes is rivaroxaban, which is approved by the U.S. FDA for venous thromboembolism prophylaxis. Chemical structure of linezolid. A first commercially available 1,3-oxazolidinone is the antibiotic linezolid.
2-Oxazolidinone is the parent compound of several protein synthesis inhibitor antibiotics and the Evans chiral auxiliaries for aldol reactions. Cycloserine is an antibiotic based on the 3-isoxazolidone parent.
The oxazolidinone pharmacophore—the chemical "template" essential for antimicrobial activity—consists of a 1,3-oxazolidin-2-one moiety with an aryl group at position 3 and an S-methyl group, with another substituent attached to it, at position 5 (the R-enantiomers of all oxazolidinones are devoid of antibiotic properties). [108]
Pages in category "Oxazolidinone antibiotics" The following 9 pages are in this category, out of 9 total. This list may not reflect recent changes. C. Cadazolid;
Contezolid (trade name Youxitai) is an antibiotic of the oxazolidinone class. [1] [2] It is effective against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus pyogenes, Streptococcus agalactiae, and other bacteria. [3]
Oxazolidinone antibiotics (9 P) 2-Oxazolidinones (13 P) Pages in category "Oxazolidinones" The following 10 pages are in this category, out of 10 total.
[6] [7] [8] [3] Tedizolid is a second-generation oxazolidinone derivative that is 4-to-16-fold more potent against staphylococci and enterococci compared to linezolid. [9] The recommended dosage for treatment is 200 mg once daily for a total duration of six days, either orally (with or without food) or through an intravenous injection (if ...
Posizolid is an oxazolidinone antibiotic under investigation by AstraZeneca for the treatment of bacterial infections. At a concentration of 2 mg/L it inhibited 98% of all Gram-positive bacteria tested in vitro. [1]