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SR 20 was co-signed with US 72 Alt. from Muscle Shoals to Huntsville. SR 20 has since been truncated to the junction of I-65 just east of Decatur. Originally, US 72 Alt. turned off of SR 20 on to SR 53 (Jordan Lane) in Huntsville and followed it north 1-mile (1.6 km) to rejoin with US 72.
Natchez Trace Parkway Bridge Natchez Trace Parkway: Colbert County to Lauderdale County: O'Neal Bridge: US 43 / US 72: Florence to Muscle Shoals: Railroad Bridge pedestrian trail that spans half the river, former Louisville and Nashville Railroad bridge
Alternate U.S. Route 72 (US 72 Alt.) exists in Alabama on the south side of the Tennessee River between Muscle Shoals and Decatur, while US 72 follows on the north side of the river between Florence and Athens. US 72 Alt. crosses the Tennessee River at Decatur, along with US 31, and follows the entire route of Interstate 565 (I-565).
SR 20 was started when Alabama renumbered SR 41 with a statewide renumbering in 1929. The original route passed from US 72 at Muscle Shoals to US 31 at Decatur. This portion was named the Joe Wheeler Highway, and markers commemorating this are still located on East (Decatur at Railroad/Church Streets) and West (Tuscumbia-Old Lee Highway) ends.
State Route 133 (SR 133) is a 16.976-mile-long (27.320 km) mostly multi-lane state highway and is a primary artery through the Florence–Muscle Shoals metropolitan area in the northwestern part of the U.S. state of Alabama.
Cherokee is situated along U.S. Route 72 west of Muscle Shoals and a few miles east of the Alabama-Mississippi state line. The Tennessee River passes to the northeast. Via US-72, Tuscumbia, the county seat of Colbert County, is 18 mi (29 km) east, and Iuka, Mississippi is 14 mi (23 km) northwest.
Florence is the largest and principal city of the "Quad Cities," more commonly known as "The Shoals," which also includes the cities of Muscle Shoals, Sheffield, and Tuscumbia in Colbert County and had a population of 148,779 as of the 2020 census. Florence is considered northwestern Alabama's primary economic hub.
US 90 in Prichard, AL: I-65 in Satsuma, AL; US 84 in Grove Hill, AL; US 80 in Demopolis, AL; US 11 from Eutaw to Tuscaloosa, AL; I-20 / I-59 south of Knoxville, AL; I-22 / US 78 in Hamilton, AL; US 72 from Muscle Shoals to near Killen, AL; US 64 in Lawrenceburg, TN; North end: US 31 / US 412 in Columbia, TN: Location; Country: United States: States
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