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In medicine, the presence of elevated transaminases, commonly the transaminases alanine transaminase (ALT) and aspartate transaminase (AST), may be an indicator of liver dysfunction. [ 1 ] [ 2 ] Other terms include transaminasemia , [ 3 ] and elevated liver enzymes (though they are not the only enzymes in the liver).
The proportion of AST to ALT in hepatocytes is about 2.5:1, but because AST is removed from serum by the liver sinusoidal cells twice as quickly (serum half-life t 1/2 = 18 hr) compared to ALT (t 1/2 = 36 hr), so the resulting serum levels of AST and ALT are about equal in healthy individuals, resulting in a normal AST/ALT ratio around 1.
Aspartate transaminase (AST) or aspartate aminotransferase, also known as AspAT/ASAT/AAT or (serum) glutamic oxaloacetic transaminase (GOT, SGOT), is a pyridoxal phosphate (PLP)-dependent transaminase enzyme (EC 2.6.1.1) that was first described by Arthur Karmen and colleagues in 1954.
When the total serum bilirubin increases over 95th percentile for age during the first week of life for high risk babies, it is known as hyperbilirubinemia of the newborn (neonatal jaundice) and requires light therapy to reduce the amount of bilirubin in the blood. Pathological jaundice in newborns should be suspected when the serum bilirubin ...
AST SpaceMobile (NASDAQ: ASTS) was in that group until shares exploded higher earlier this year. The stock is now approaching $30, a 550% return over the past year. The stock is now approaching ...
Enzyme activity is commonly used for e.g. liver function tests like AST, ALT, ... 47 [26] 81 , [26] 85 [26] μmol/L ... bicarbonate and base excess show a high level ...
AST SpaceMobile stock has cooled down in recent months and is 41% below its 52-week high price of almost $39 per share in August. AST SpaceMobile (NASDAQ: ASTS) is one intriguing company making ...
The low earth orbit (LEO) satellite developer's stock started trading at $11.63 on the first day, sank to around $2 this April, and skyrocketed to a record high of $38.60 on Aug. 19.