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Interstate 26. Connecting directly from I-81, I-26 offers another major corridor for travel between East Tennessee and the Carolinas. Motorists can use this route to travel south from I-81 toward ...
U.S. Route 441 (US 441) is a north–south United States Highway that runs from Miami, Florida to Rocky Top, Tennessee.In the U.S. state of North Carolina, US 441 travels for 64.5 miles (103.8 km) from the Georgia state line near Dillard, Georgia to the Tennessee state line in the Great Smoky Mountains National Park.
US 441 merges with US 23, remaining concurrent with the route through Clayton (where US 23 and US 441 are concurrent with U.S. Route 76 for a short distance) into North Carolina. The portion of US 23 / US 441 from U.S. Route 123 west of Toccoa to the North Carolina state line is located within the Chattahoochee National Forest .
U.S. Route 64 (US 64) is an east–west United States highway that runs for 2,281 miles (3,672 km) from Nags Head in eastern North Carolina to just southwest of the Four Corners in northeast Arizona.
U.S. Route 421 (US 421) is part of the United States Numbered Highway System that runs from Fort Fisher, North Carolina to Michigan City, Indiana.In the U.S. state of North Carolina, US 421 travels 328 miles (528 km) from its southern terminus at Fort Fisher to the Tennessee state line near the community of Zionville, North Carolina.
Interstate 40 (I-40) is a part of the Interstate Highway System that travels 2,556.61 miles (4,114.46 km) from Barstow, California, to Wilmington, North Carolina.In North Carolina, I-40 travels 420.21 miles (676.26 km) across the entirety of the state from the Tennessee state line along the Pigeon River Gorge to U.S. Highway 117 (US 117) and North Carolina Highway 132 (NC 132) in Wilmington.
I-40 / I-275 – Nashville, Asheville, NC, Lexington, KY: I-40 exit 388; I-275 exit 0A: SR 62 west (Western Avenue) – Karns, Oak Ridge: Eastern terminus of SR 62: West Fifth Avenue – Asheville, NC: Former northern end of US 11/US 70/SR 1 concurrency; SR 33 turns primary: Hall of Fame Drive (unsigned SR 71 south)
U.S. Route 70 (US 70) is a part of the United States Numbered Highway System that runs from Globe, Arizona, to the Crystal Coast of the US state of North Carolina.In North Carolina, it is a major 488-mile-long (785 km) east–west highway that runs from the Tennessee border to the Atlantic Ocean.