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The 5' UTR is upstream from the coding sequence. Within the 5' UTR is a sequence that is recognized by the ribosome which allows the ribosome to bind and initiate translation. The mechanism of translation initiation differs in prokaryotes and eukaryotes. The 3' UTR is found immediately following the translation stop codon.
The 5′ untranslated region (also known as 5′ UTR, leader sequence, transcript leader, or leader RNA) is the region of a messenger RNA (mRNA) that is directly upstream from the initiation codon. This region is important for the regulation of translation of a transcript by differing mechanisms in viruses , prokaryotes and eukaryotes .
(See Central dogma of molecular biology). mRNA structure, approximately to scale for a human mRNA, where the median length of 3′UTR is 700 nucleotides. In molecular genetics, the three prime untranslated region (3′-UTR) is the section of messenger RNA (mRNA) that immediately follows the translation termination codon.
In protein-coding genes, the exons include both the protein-coding sequence and the 5′- and 3′-untranslated regions (UTR). Often the first exon includes both the 5′-UTR and the first part of the coding sequence, but exons containing only regions of 5′-UTR or (more rarely) 3′-UTR occur in some genes, i.e. the UTRs may contain introns. [11]
The 5′-untranslated region (5′-UTR) is a region of a gene which is transcribed into mRNA, and is located at the 5′-end of the mRNA. This region of an mRNA may or may not be translated , but is usually involved in the regulation of translation.
In DNA, regulation of gene expression normally happens at the level of RNA biosynthesis (transcription).It is accomplished through the sequence-specific binding of proteins (transcription factors) that activate or inhibit transcription.
The 3' untranslated region of mRNA labeled 3' UTR. Normally about 700 nucleotides in human mRNA. A silencer is a sequence-specific element that induces a negative effect on the transcription of its particular gene. There are many positions in which a silencer element can be located in DNA.
This base pairing comes about by the scanning mechanism that ensues once the small 40S ribosomal subunit binds the 5' untranslated region (UTR) of mRNA. The usage of this scanning mechanism, in opposition to the Shine-Dalgarno sequence that was referenced in prokaryotes, is the ability to regulate translation through upstream RNA secondary ...