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Actinic granuloma is distinguished histopathologically by multinucleated foreign body giant cells that phagocytize the degenerated elastic fibers, a process known as elastophagocytosis. At the solar elastosis level, there is no necrobiosis , such as facial necrobiosis lipoidica , or mucinosis , such as GA or sarcoid-like granuloma in the dermis.
Granuloma; Picture of a granuloma (without necrosis) as seen through a microscope on a glass slide: The tissue on the slide is stained with two standard dyes (hematoxylin: blue, eosin: pink) to make it visible. The granuloma in this picture was found in a lymph node of a patient with a Mycobacterium avium infection. Specialty: Pathology
Actinic granuloma (O'Brien granuloma) Annular elastolytic giant cell granuloma (giant cell elastophagocytosis, Meischer's granuloma, Miescher's granuloma of the face) Annular sarcoidosis Generalized granuloma annulare; Benign cephalic histiocytosis (histiocytosis with intracytoplasmic worm-like bodies)
Caseous necrosis in the kidney. In caseous necrosis no histological architecture is preserved (unlike with coagulative necrosis). [5] [6] On microscopic examination with H&E staining, the area is acellular, characterised by amorphous, roughly granular eosinophilic debris of now dead cells, [6] also containing interspearsed haematoxyphilic remnants of cell nucleus contents. [5]
Multinucleated giant cells due to an infection. H&E stain.. A giant cell (also known as a multinucleated giant cell, or multinucleate giant cell) is a mass formed by the union of several distinct cells (usually histiocytes), often forming a granuloma.
An asteroid body is a microscopic finding seen within the giant cells of granulomas in diseases such as sarcoidosis and foreign-body giant cell reactions. [1] There is controversy about their composition. Traditionally, they were thought to be cytoskeletal elements and to consist primarily of vimentin. [2]
Histopathologically, an annular elastolytic giant-cell granuloma exhibits a granulomatous reaction accompanied by phagocytosis of the elastic fibers, elastolysis, and multinucleate giant cells devoid of or reduced in elastin fibers. Other hallmarks of the histopathology include the lack of mucin deposition and collagen necrobiosis. [7]
Actinic keratosis (AK), sometimes called solar keratosis or senile keratosis, [1] [2] is a pre-cancerous [3] area of thick, scaly, or crusty skin. [ 4 ] [ 5 ] Actinic keratosis is a disorder ( -osis ) of epidermal keratinocytes that is induced by ultraviolet (UV) light exposure ( actin- ).