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Structures with names 4- and 5-nitroimidazole are equivalent from the perspective of drugs since these tautomers readily interconvert. Drugs of the 5-nitro variety include metronidazole, tinidazole, nimorazole, dimetridazole, pretomanid, ornidazole, megazol, and azanidazole. Drugs based on 2-nitroimidazoles include benznidazole and azomycin. [3]
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2-Methylimidazole is an organic compound that is structurally related to imidazole with the chemical formula CH 3 C 3 H 2 N 2 H. It is a white or colorless solid that is highly soluble in polar organic solvents and water. It is a precursor to a range of drugs and is a ligand in coordination chemistry.
2-Methylimidazole (1) may be prepared via the Debus-Radziszewski imidazole synthesis, or from ethylenediamine and acetic acid, followed by treatment with lime, then Raney nickel. 2-Methylimidazole is nitrated to give 2-methyl-4(5)-nitroimidazole (2), which is in turn alkylated with ethylene oxide or 2-chloroethanol to give metronidazole (3 ...
Methylimidazole may refer to several related chemical compounds: 1-Methylimidazole; 2-Methylimidazole; 4-Methylimidazole, which is chemically distinct from, but readily interconvertable with 5-methylimidazole
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(CHO) 2 + CH 2 O + CH 3 NH 2 + NH 3 → H 2 C 2 N(NCH 3)CH + 3 H 2 O. The compound can be synthesized on a laboratory scale by methylation of imidazole at the pyridine-like nitrogen and subsequent deprotonation. [4] Similarly, 1-methylimidazole may be synthesized by first deprotonating imidazole to form a sodium salt followed by methylation. [5 ...
Create account; Log in; Pages for logged out editors learn more. Contributions; Talk; ... O-Methyl [2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]carbamothioate. CAS ...