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Noonan syndrome with multiple lentigines (NSML) which is part of a group called Ras/MAPK pathway syndromes, [2] is a rare autosomal dominant, [3] multisystem disease caused by a mutation in the protein tyrosine phosphatase, non-receptor type 11 gene . The disease is a complex of features, mostly involving the skin, skeletal and cardiovascular ...
The LAMB acronym refers to lentigines, atrial myxomas, and blue nevi. [1] NAME refers to nevi, atrial myxoma, myxoid neurofibromas, and ephelides. [1] Testicular cancer, particularly Sertoli cell type, is associated with Carney syndrome. [7] Thyroid and pancreas cancer may also occur. [8] [9]
A lentigo (/ l ɛ n ˈ t aɪ ɡ oʊ /) (plural lentigines, / l ɛ n ˈ t ɪ dʒ ɪ n iː z /) is a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin. It is a harmless (benign) hyperplasia of melanocytes which is linear in its spread.
Familial multiple lentigines syndrome without systemic involvement [1] Generalized lentiginosis is inherited in an autosomal dominant manner: Specialty:
Noonan syndrome (NS) is a genetic disorder that may present with mildly unusual facial features, short height, congenital heart disease, ...
Lentigo in cats is a common dermatological condition characterized by the presence of small, flat, brownish spots on the skin — particularly around the lips, nose, and eyelid margins.
Lentiginosis refers to the presence of lentigines in large numbers or in a distinctive configuration. [1] These are spotted areas created by accumulation in the skin due to sun exposure. Due to a high irregularity any distinction from randomness defines lentiginosis.
Centrofacial lentiginosis is a cutaneous condition characterized by lentigines on the nose and adjacent cheeks. [1]: 686 The condition is associated with sacral hypertrichosis, developmental delay, seizures, absent middle incisors, skeletal, abnormalities, dwarfism, endocrine dysfunction and congenital mitral valve stenosis. [2]