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Cardiac glycosides are a class of organic compounds that increase the output force of the heart and decrease its rate of contractions by inhibiting the cellular sodium-potassium ATPase pump. [1] Their beneficial medical uses include treatments for congestive heart failure and cardiac arrhythmias ; however, their relative toxicity prevents them ...
Cardiac glycosides like digoxin, primarily inhibit the sodium-potassium pump (Na+/K+ ATPase), an important protein located on the surface of cardiomyocytes (cardiac muscle cells). [ 1 ] [ 2 ] Using ATP (the cell’s energy currency), this protein facilitates the transport of extracellular potassium ions (K+) into the cell while exporting sodium ...
Lanatoside C (or isolanid) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). Lanatoside C can be used orally [1] or by the intravenous route. [2] It is marketed in a number of countries and is also available in generic form. [3]
This treatment is used for digoxin poisoning, another cardiac glycoside. [16] Supportive care like monitoring vitals and electrolyte and fluid balance is important. Patients may present hypovolemic due to vomiting and diarrhea, but severely elevated potassium can also occur. [17]
Cerberin is a type of cardiac glycoside, found in the seeds of the dicotyledonous angiosperm genus Cerbera; including the suicide tree (Cerbera odollam) and the sea mango (Cerbera manghas). As a cardiac glycoside, cerberin disrupts the function of the heart by blocking its sodium and potassium ATPase . [ 2 ]
The term derives from card-"heart" (from Greek καρδία kardiā) and the suffix -enolide, referring to the lactone ring at C17. [2] Cardenolides are a class of steroids (or aglycones if viewed as cardiac glycoside constituents), and cardenolides are a subtype of this class (see MeSH D codes list).
It was known that ouabain was a cardiac poison, but there was some speculation about its potential medical uses. [5] [22] In 1882, ouabain was first isolated from the plant by the French chemist Léon-Albert Arnaud as an amorphous substance, which he identified as a glycoside. [5] Ouabain was seen as a possible treatment for certain cardiac ...
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