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Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene. [5] [6] This gene is located within the Smith–Magenis syndrome region on chromosome 17.
Sterol+Regulatory+Element+Binding+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) The Brown and Goldstein Lab Archived 2009-05-26 at the Wayback Machine. Cholesterol Synthesis Archived 2017-07-04 at the Wayback Machine - has some good regulatory details; Protein Data Base (PDB), Sterol Regulatory Element ...
SCAP is a regulatory protein that is required for the proteolytic cleavage of the sterol regulatory element-binding protein . SCAP is an integral membrane protein located in the endoplasmic reticulum (ER). One of the cytosolic regions of SCAP contains a hexapeptide amino acid sequence, MELADL, that functions to detect cellular cholesterol. When ...
Membrane-bound transcription factor site-1 protease, or site-1 protease (S1P) for short, also known as subtilisin/kexin-isozyme 1 (SKI-1), is an enzyme (EC 3.4.21.112) that in humans is encoded by the MBTPS1 gene. [5] S1P cleaves the endoplasmic reticulum loop of sterol regulatory element-binding protein (SREBP) transcription factors. [6] [7]
The main regulatory mechanism is the sensing of intracellular cholesterol in the endoplasmic reticulum by the protein SREBP (sterol regulatory element-binding protein 1 and 2). [45] In the presence of cholesterol, SREBP is bound to two other proteins: SCAP (SREBP cleavage-activating protein) and INSIG-1.
Several key enzymes can be activated through DNA transcriptional regulation on activation of SREBP (sterol regulatory element-binding protein-1 and -2). This intracellular sensor detects low cholesterol levels and stimulates endogenous production by the HMG-CoA reductase pathway, as well as increasing lipoprotein uptake by up-regulating the LDL ...
Membrane-bound transcription factor site-2 protease, also known as S2P endopeptidase or site-2 protease (S2P), is an enzyme (EC 3.4.24.85) encoded by the MBTPS2 gene which liberates the N-terminal fragment of sterol regulatory element-binding protein (SREBP) transcription factors from membranes.
Examples include Microphthalmia-associated transcription factor and Sterol regulatory element binding protein (SREBP). External links