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Oropharyngeal cancer, [1] [2] [3] also known as oropharyngeal squamous cell carcinoma and tonsil cancer, [1] is a disease in which abnormal cells with the potential to both grow locally and spread to other parts of the body are found in the oral cavity, in the tissue of the part of the throat that includes the base of the tongue, the tonsils, the soft palate, and the walls of the pharynx.
Squamous-cell carcinoma (SCC), also known as epidermoid carcinoma, comprises a number of different types of cancer that begin in squamous cells. [1] These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the respiratory and digestive tracts .
Carcinoma of the tonsil is a type of squamous cell carcinoma. The tonsil is the most common site of squamous cell carcinoma in the oropharynx. It comprises 23.1% of all malignancies of the oropharynx. [1] The tumors frequently present at advanced stages, and around 70% of patients present with metastasis to the cervical lymph nodes. [2].
Inhibits DNA and to a lesser extent RNA synthesis, produces single and double strand breaks in DNA possibly by free radical formation. Germ cell tumours, squamous cell carcinoma, pancreatic cancer, non-Hodgkin's, pleural sclerosing and Hodgkin's lymphoma. Pulmonary toxicity, hypersensitivity, scleroderma and Raynaud's phenomenon. Bortezomib: IV, SC
A survey of 23 countries between 1983 and 2002 showed an increase in oropharyngeal squamous cell carcinoma that was particularly noticeable in young men in economically developed countries. [220] [12] In the United Kingdom the incidence of oral and oropharyngeal cancer in men rose 51%, from 7/100,000 to 11/100,000 between 1989 and 2006. [233]
There is a risk of metastasis starting more than 10 years [citation needed] after diagnosable appearance of squamous-cell carcinoma, but the risk is low, [specify] though much [specify] higher than with basal-cell carcinoma. Squamous-cell cancers of the lip and ears have high rates of local recurrence and distant metastasis. [27]
Multi-Disciplinary Treatment Often, successful treatment of and recovery from laryngeal cancer will involve expertise outside of the realms of surgery or oncology . Physical therapists , occupational therapists , speech therapists , psychiatrists , psychologists , oral/maxillofacial surgeons , dentists , neurologists , neurosurgeons , and ...
Verrucous carcinoma may occur in various head and neck locations, as well as in the genitalia or sole of the foot. The oral cavity is the most common site of this tumor. [6] The ages range from 50 to 80 years with a male predominance and a median age of 67 years. [7]