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The hepatocyte is a cell in the body that manufactures serum albumin, fibrinogen, and the prothrombin group of clotting factors (except for Factors 3 and 4). It is the main site for the synthesis of lipoproteins , ceruloplasmin , transferrin , complement , and glycoproteins .
The main liver cells are called hepatocytes; however, there are other cells that can be observed in a liver sample such as Kupffer cells (macrophages). [2] The liver is the biggest gland of the body. It has a wide variety of functions that range from the destruction of old blood cells to the control of the whole metabolism of macromolecules . [ 3 ]
In histology (microscopic anatomy), the lobules of liver, or hepatic lobules, are small divisions of the liver defined at the microscopic scale. The hepatic lobule is a building block of the liver tissue, consisting of a portal triad, hepatocytes arranged in linear cords between a capillary network, and a central vein.
In the liver, large areas of the tissues are formed but for the formation of new cells there must be sufficient amount of material so the circulation of the blood becomes more active. [78] This is predominantly due to the hepatocytes re-entering the cell cycle. That is, the hepatocytes go from the quiescent G0 phase to the G1 phase and undergo ...
Each cell has several long cytoplasmic protrusions that extend from the cell body and wrap around the sinusoids. [5] The lipid droplets in the cell body store vitamin A as retinyl palmitate. [6] Hepatic stellate cells store 50–80% of the body's vitamin A. [6] The function and role of quiescent hepatic stellate cells is unclear.
Hepatocytes are polyhedral in shape, therefore having no set shape or design, although they are made of cuboidal epithelial cells. They have surfaces facing the sinusoids (called sinusoidal faces) and surfaces which contact other hepatocytes (called lateral faces). Bile canaliculi are formed by grooves on some of the lateral faces of these ...
Albumin, carries thyroid hormones and other hormones, particularly fat soluble ones, fatty acids to the liver, unconjugated bilirubin, many drugs and Ca 2+; Ceruloplasmin, carries copper
As a result, the partial gas pressure of oxygen (pO 2) and perfusion pressure of portal blood are lower than in other organs of the body. Blood passes from branches of the portal vein through cavities between "plates" of hepatocytes called sinusoids.