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Meclofenoxate (INN, BAN; brand name Lucidril, also known as centrophenoxine) is a cholinergic nootropic used as a dietary supplement. [2] [3] [4] It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA). In elderly patients, meclofenoxate has been shown to improve performance on certain memory tests. [5]
Minor gastrointestinal upset (nausea, vomiting, flatulence, etc.) in predisposed individuals, or when taken between meals: adjust dosage individually, and/or add domperidone; Orthostatic hypotension or drowsiness may occur, particularly in predisposed individuals (underlying condition or causative illness);
Pseudoephedrine has been used in the form of the hydrochloride and sulfate salts and in a polistirex form. [30] The drug has been used in more than 135 over-the-counter and prescription formulations. [22] Many prescription formulations containing pseudoephedrine have been discontinued over time. [30]
Its use was pioneered in the Czech Republic, where it was first noted that use greatly decreases mortality among elderly. [ 31 ] [ 32 ] In 2022, a large Phase 3 trial concluded that administration of inosine pranobex should start as early as possible with greatly improved outcomes in mild to moderate COVID-19 patients.
Servier states that the use is now restricted to treatment of severe osteoporosis in postmenopausal women at high risk for fracture. [2] The European Pharmacovigilance Risk Assessment Committee (PRAC) recommended restriction in the use of strontium ranelate, based on a routine benefit-risk assessment of the medicine, which included data showing ...
For venous insufficiency, the dosage is 2 tablets of 500mg daily. For acute hemorrhoidal attack, the dosage is 6 tablets daily for 4 days, followed by 4 tablets daily over the next 3 days. [15] For chronic venous disease, the dosage is 2 tablets a day for at least 2 months. [16]
Pizotifen, also known as pizotyline and sold under the brand names Sandomigran and Mosegor among others, is an antimigraine agent of the tricyclic group which is used primarily as a preventative to reduce the frequency of recurrent migraine headaches. [1]
Deaths that have occurred from diflunisal usually involved mixed drugs and or extremely high dosage. The oral LD 50 is 500 mg/kg. Symptoms of overdose include coma, tachycardia, stupor, and vomiting. The lowest dose without the presence of other medicines which caused death was 15 grams.