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AOH1996 was created to target a post-translationally modified isoform of PCNA, termed caPCNA, which is preferentially found in cancer cells. PCNA is crucial in the body for DNA repair , but targeting it is difficult because of its role in healthy cells.
Scientists hope findings signal a major breakthrough in tackling leading cause of cancer deaths
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Mercaptopurine (6-MP), sold under the brand name Purinethol among others, is a medication used for cancer and autoimmune diseases. [2] Specifically it is used to treat acute lymphocytic leukemia (ALL), acute promyelocytic leukemia (APL), Crohn's disease, and ulcerative colitis.
An oral pill in clinical trials shows promising results in lung cancer patients with advanced disease. Lung cancer is the third most common cancer in the U.S., according to the Centers for Disease ...
Steven Manetta takes at least a half dozen pills daily to help keep a form of leukemia in remission. For more than a year, he rationed his go-to anti-nausea pill, ondansetron, known by the brand-name Zofran. Manetta’s coverage through CVS Caremark paid for 18 ondansetron pills every 21 days.
Acalabrutinib, sold under the brand name Calquence, is a anti-cancer medication used to treat various types of non-Hodgkin lymphoma, including mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma. [7] It may be used both in relapsed as well as in treatment-naive settings. [8]