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The EFSA does not consider chromium to be an essential nutrient, and so has not set PRIs, AIs or ULs. Chromium is the only mineral for which the United States and the European Union disagree on essentiality. [7] [13] For U.S. food and dietary supplement labeling purposes, the amount in a serving is expressed as a percent of Daily Value (%DV).
Although some research suggested that chromium(III) picolinate may assist in weight loss and increase muscle mass, a 2013 Cochrane review was unable to find "reliable evidence to inform firm decisions" to support such claims. [3] Among the transition metals, Cr 3+ is the most controversial in terms of nutritional value and toxicity.
The incidence of liver damage from herbal and dietary supplements is about 16–20% of all supplement products causing injury, with the occurrence growing globally over the early 21st century. [2] The most common liver injuries from weight loss and bodybuilding supplements involve hepatocellular damage and jaundice.
In one study, juvenile fish gained weight on a zero chromium diet, but the addition of 500 μg of chromium in the form of chromium chloride or other supplement types, per kilogram of food (dry weight), increased weight gain. At 2,000 μg/kg the weight gain was no better than with the zero chromium diet, and there were increased DNA strand breaks.
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Iron supplements, also known as iron salts and iron pills, are a number of iron formulations used to treat and prevent iron deficiency including iron deficiency anemia. [ 11 ] [ 12 ] For prevention they are only recommended in those with poor absorption , heavy menstrual periods , pregnancy , hemodialysis , or a diet low in iron.
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