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The kidneys excrete a variety of waste products produced by metabolism into the urine. The microscopic structural and functional unit of the kidney is the nephron. It processes the blood supplied to it via filtration, reabsorption, secretion and excretion; the consequence of those processes is the production of urine.
Diagram showing the basic physiologic mechanisms of the kidney. The kidney's ability to perform many of its functions depends on the three fundamental functions of filtration, reabsorption, and secretion, whose sum is called renal clearance or renal excretion. That is:
Diagram outlining movement of ions in nephron, with the collecting ducts on the right. The collecting duct system is the final component of the kidney to influence the body's electrolyte and fluid balance. In humans, the system accounts for 4–5% of the kidney's reabsorption of sodium and 5% of the kidney's reabsorption of water. At times of ...
Fig.1) Schematic diagram of the nephron (yellow), relevant circulation (red/blue), and the four methods of altering the filtrate. The nephron is the functional unit of the kidney. [3] This means that each separate nephron is where the main work of the kidney is performed. A nephron is made of two parts:
This is an accepted version of this page This is the latest accepted revision, reviewed on 5 February 2025. This article is about the human urinary system. For urinary systems of other vertebrates, see Urinary systems of birds, urinary systems of reptiles, and urinary systems of amphibians. Anatomical system consisting of the kidneys, ureters, urinary bladder, and the urethra Urinary system 1 ...
The kidneys are a pair of organs of the excretory system in vertebrates, which maintain the balance of water and electrolytes in the body (osmoregulation), filter the blood, remove metabolic waste products, and, in many vertebrates, also produce hormones (in particular, renin) and maintain blood pressure.
Mammalian kidneys are susceptible to ischemic injury because mammals lack a renal-portal system, and as a result, vascular vasoconstriction in the glomeruli can lead to decreased blood supply to the entire kidney. The kidneys are susceptible to toxic injury, since toxins are reabsorbed in the tubules along with most of the filtered substances. [47]
In renal physiology, renal chloride reabsorption refers to the process by which the kidneys, having filtered out waste products from the blood to be excreted as urine, re-absorb chloride ions (Cl −) from the waste.