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Cancer cells have unique features that make them "immortal" according to some researchers. The enzyme telomerase is used to extend the cancer cell's life span. While the telomeres of most cells shorten after each division, eventually causing the cell to die, telomerase extends the cell's telomeres. This is a major reason that cancer cells can ...
Cancers are caused by a series of mutations. Each mutation alters the behavior of the cell somewhat. Cancer is fundamentally a disease of tissue growth regulation. For a normal cell to transform into a cancer cell, the genes that regulate cell growth and differentiation must be altered. [98] The affected genes are divided into two broad categories.
Cancer is caused by genetic changes leading to uncontrolled cell growth and tumor formation. The basic cause of sporadic (non-familial) cancers is DNA damage and genomic instability. [1] [2] A minority of cancers are due to inherited genetic mutations. [3] Most cancers are related to environmental, lifestyle, or behavioral exposures. [4]
This is an accepted version of this page This is the latest accepted revision, reviewed on 13 February 2025. African-American woman (1920–1951), source of HeLa immortal cell line "Lacks" redirects here. For other uses, see Lack. Henrietta Lacks Lacks c. 1945–1951. Born Loretta Pleasant (1920-08-01) August 1, 1920 Roanoke, Virginia, U.S. Died October 4, 1951 (1951-10-04) (aged 31) Baltimore ...
Cancer and serious health topics can be stigmatized and tough to talk about, Vilar-Sanchez says, but it's important to know who in your family has had cancer, what type of cancer and any other ...
In cancer cells, major changes in gene expression increase glucose uptake to support their rapid growth. Unlike normal cells, which produce lactate only when oxygen is low, cancer cells convert much of the glucose to lactate even in the presence of adequate oxygen. This is known as the “Warburg Effect.”
The cancer stem cell model, also known as the Hierarchical Model proposes that tumors are hierarchically organized (CSCs lying at the apex [6] (Fig. 3).) Within the cancer population of the tumors there are cancer stem cells (CSC) that are tumorigenic cells and are biologically distinct from other subpopulations [7] They have two defining features: their long-term ability to self-renew and ...
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