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In a placebo-controlled clinical trial, any change in the control group is known as the placebo response, and the difference between this and the result of no treatment is the placebo effect. [4] Placebos in clinical trials should ideally be indistinguishable from so-called verum treatments under investigation, except for the latter's ...
A clinical control group can be a placebo arm or it can involve an old method used to address a clinical outcome when testing a new idea. For example in a study released by the British Medical Journal, in 1995 studying the effects of strict blood pressure control versus more relaxed blood pressure control in diabetic patients, the clinical control group was the diabetic patients that did not ...
The structure of this trial is significant because, in those days, the only time placebos were ever used "was to express the efficacy or non-efficacy of a drug in terms of "how much better" the drug was than the "placebo". [18]: 88 (Note that the trial conducted by Austin Flint is an example of such a drug efficacy vs. placebo efficacy trial.)
The word placebo was used in a medicinal context in the late 18th century to describe a "commonplace method or medicine" and in 1811 it was defined as "any medicine adapted more to please than to benefit the patient". Although this definition contained a derogatory implication, [1] it did not necessarily imply that the remedy had no effect. [2]
For example, precisely the same inert agents can produce analgesia and hyperalgesia, the first of which, on this definition, would be a placebo, and the second a nocebo. [31] A second problem is that the same effect, such as immunosuppression, may be desirable for a subject with an autoimmune disorder, but undesirable for most other subjects.
In scientific research and psychotherapy, the subject-expectancy effect, is a form of reactivity that occurs when a research subject expects a given result and therefore unconsciously affects the outcome, or reports the expected result.
Observer-expectancy effect (cognitive biases) (cognitive psychology) Occlusion effect (biology) (otology) Octave effect (effects units) Okorokov effect (physics) Oligodynamic effect (biology and pharmacology of chemical elements) Online disinhibition effect (Internet culture) (psychology) Onnes effect (condensed matter physics) (fluid mechanics ...
An example of an active placebo is the 1964 work of Shader and colleagues who used a combination of low-dose phenobarbital plus atropine to mimic the sedation and dry mouth produced by phenothiazines. Morphine and gabapentin are painkillers with the common side effects of sleepiness and dizziness.