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In the pharmaceutical industry, drug dissolution testing is routinely used to provide critical in vitro drug release information for both quality control purposes, i.e., to assess batch-to-batch consistency of solid oral dosage forms such as tablets, and drug development, i.e., to predict in vivo drug release profiles. [1]
The tablet is pushed against a stationary anvil until it fractures. A reading is taken from a scale indicator. [5] Kraemer Elektronik's tablet testing system was the first automatic tablet hardness testing system for auto-regulation at tablet presses, invented by German mechanical engineer Mr. Norbert Kraemer in Darmstadt, Germany.
A tablet is usually a compressed preparation that contains: 5-10% of the drug (active substance); 80% of fillers, disintegrants, lubricants, glidants, and binders; and; 10% of compounds which ensure easy disintegration, disaggregation, and dissolution of the tablet in the stomach or the intestine.
In pharmaceutics, sink condition is a term mostly related to the dissolution testing procedure.. It means using a sheer volume of solvent, usually about 5 to 10 times greater than the volume present in the saturated solution of the targeted chemical (often the API, and sometimes the excipients) contained in the dosage form being tested.
The physical properties of a tablet are tested either by manual or automated sampling and IPC testing (in-process control). Tablet "hardness", also called "breaking force", is tested to assure that the tablet's strength will survive all further processes, such as dedusting, coating and packaging.
Thermal desorption is an environmental remediation technology that utilizes heat to increase the volatility of contaminants such that they can be removed (separated) from the solid matrix (typically soil, sludge or filter cake). The volatilized contaminants are then either collected or thermally destroyed.
A soil test is a laboratory or in-situ analysis to determine the chemical, physical or biological characteristics of a soil. Possibly the most widely conducted soil tests are those performed to estimate the plant-available concentrations of nutrients in order to provide fertilizer recommendations in agriculture.
Effervescent or carbon tablets are tablets which are designed to dissolve in water and release carbon dioxide. The carbon dioxide is generated by a reaction of a compound containing bicarbonate , such as sodium bicarbonate or magnesium bicarbonate , with an acid such as citric acid or tartaric acid .