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Cis AB is a type of rare mutation in the ABO gene. It happens when the transferase allele contains a mix of amino acids from either A or B alleles, producing a bifunctional enzyme that can produce both types of antigens, usually with one weaker than the other. This results in a serum test result much like the standard, separate (trans) AB ...
This usage can be seen in the cis–trans distinction in chemistry, the cis and trans sides of the Golgi apparatus in cellular biology, the ancient Roman term Cisalpine Gaul (i.e. 'Gaul on this side of the Alps'), and Cisjordan (as distinguished from Transjordan). In cisgender, cis-describes the alignment of gender identity with assigned sex ...
Additionally, each trans-regulatory element affects a large number of genes on both alleles, [2] while cis-regulatory element is allele specific [1] [2] and only controls genes nearby. Exonic and promoter sequences of the genes are significantly more conserved than the genes in cis- and trans- regulatory elements. [3]
A recent research paper using this definition [2] reported cases of transvection between different alleles of Hsp90. This second definition is also sometimes applied to the situation where two different chromosomal deletions exist in trans (on the different homologous chromosomes) and fail to complement because they disrupt one or more common ...
Since the mutations are recessive, the offspring will display the wild-type phenotype. A complementation test (sometimes called a "cis-trans" test) can test whether the mutations in two strains are in different genes. Complementation is usually weaker or absent if the mutations are in the same gene.
Some cis eQTLs are detected in many tissue types but the majority of trans eQTLs are tissue-dependent (dynamic). [10] eQTLs may act in cis (locally) or trans (at a distance) to a gene. [11] The abundance of a gene transcript is directly modified by polymorphism in regulatory elements. Consequently, transcript abundance might be considered as a ...
The haplotype encodes DQ2.5 cis isoform, referring to the cis arrangement of the DQA1*05 01 and DQB1*02 01 on the same variant of chromosome 6. The isoform can also be encoded trans-haplotype (between two sister chromosomes) forming the DQ2.5 trans isoform. This isoform occurs when a person has the DQ7.5/DQ2.2 phenotype.
Very often, cis–trans stereoisomers contain double bonds or ring structures. In both cases the rotation of bonds is restricted or prevented. [4] When the substituent groups are oriented in the same direction, the diastereomer is referred to as cis, whereas when the substituents are oriented in opposing directions, the diastereomer is referred to as trans.