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Cis AB is a type of rare mutation in the ABO gene. It happens when the transferase allele contains a mix of amino acids from either A or B alleles, producing a bifunctional enzyme that can produce both types of antigens, usually with one weaker than the other. This results in a serum test result much like the standard, separate (trans) AB ...
Additionally, each trans-regulatory element affects a large number of genes on both alleles, [2] while cis-regulatory element is allele specific [1] [2] and only controls genes nearby. Exonic and promoter sequences of the genes are significantly more conserved than the genes in cis- and trans- regulatory elements. [3]
Cis-regulatory elements (CREs) or cis-regulatory modules (CRMs) are regions of non-coding DNA which regulate the transcription of neighboring genes.CREs are vital components of genetic regulatory networks, which in turn control morphogenesis, the development of anatomy, and other aspects of embryonic development, studied in evolutionary developmental biology.
Since the mutations are recessive, the offspring will display the wild-type phenotype. A complementation test (sometimes called a "cis-trans" test) can test whether the mutations in two strains are in different genes. Complementation is usually weaker or absent if the mutations are in the same gene.
The haplotype encodes DQ2.5 cis isoform, referring to the cis arrangement of the DQA1*05 01 and DQB1*02 01 on the same variant of chromosome 6. The isoform can also be encoded trans-haplotype (between two sister chromosomes) forming the DQ2.5 trans isoform. This isoform occurs when a person has the DQ7.5/DQ2.2 phenotype.
This is a list of cis-regulatory RNAs. These are RNA motifs which regulate nucleic acid regions on the same molecule, as opposed to trans-acting motifs which regulate a distal molecule. Some of these RNAs are broadly distributed while others are single RNA families.
Some cis eQTLs are detected in many tissue types but the majority of trans eQTLs are tissue-dependent (dynamic). [10] eQTLs may act in cis (locally) or trans (at a distance) to a gene. [11] The abundance of a gene transcript is directly modified by polymorphism in regulatory elements. Consequently, transcript abundance might be considered as a ...
Such expression QTLs (eQTLs) describe cis- and trans-controlling elements for the expression of often disease-associated genes. [16] Observed epistatic effects have been found beneficial to identify the gene responsible by a cross-validation of genes within the interacting loci with metabolic pathway- and scientific literature databases.