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Enterococcus faecium is a Gram-positive, gamma-hemolytic or non-hemolytic bacterium in the genus Enterococcus. [1] It can be commensal (innocuous, coexisting organism) in the gastrointestinal tract of humans and animals, [ 2 ] but it may also be pathogenic , causing diseases such as neonatal meningitis or endocarditis .
Enterococcus is a large genus of lactic acid bacteria of the phylum Bacillota. Enterococci are Gram-positive cocci that often occur in pairs ( diplococci ) or short chains, and are difficult to distinguish from streptococci on physical characteristics alone. [ 2 ]
Enterococcus faecalis – formerly classified as part of the group D Streptococcus system – is a Gram-positive, commensal bacterium inhabiting the gastrointestinal tracts of humans. [ 1 ] [ 2 ] Like other species in the genus Enterococcus , E. faecalis is found in healthy humans and can be used as a probiotic.
ESKAPE is an acronym comprising the scientific names of six highly virulent and antibiotic resistant bacterial pathogens including: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. [1] The acronym is sometimes extended to ESKAPEE to include Escherichia coli. [2]
Bacteremia can travel through the blood stream to distant sites in the body and cause infection (hematogenous spread). Hematogenous spread of bacteria is part of the pathophysiology of certain infections of the heart ( endocarditis ), structures around the brain ( meningitis ), and tuberculosis of the spine ( Pott's disease ).
Main article: Human parasite Endoparasites Protozoan organisms Common name of organism or disease Latin name (sorted) Body parts affected Diagnostic specimen Prevalence Source/Transmission (Reservoir/Vector) Granulomatous amoebic encephalitis and Acanthamoeba keratitis (eye infection) Acanthamoeba spp. eye, brain, skin culture worldwide contact lenses cleaned with contaminated tap water ...
Carrion's disease: Peripheral blood smear with Giemsa stain, Columbia blood agar cultures, immunoblot, indirect immunofluorescence, and PCR: Fluoroquinolones (such as ciprofloxacin) or chloramphenicol in adults and chloramphenicol plus beta-lactams in children No Bartonella henselae: Cat-scratch disease: Polymerase chain reaction: Azithromycin: No
Carbapenem covalently binds to PBPs, which causes transpeptidases to irreversibly lose their catalytic activity. [19] Inhibition of transpeptidases prevents the formation of cross-links between peptidoglycan polymers and causes a build-up of peptidoglycan precursors. Newly formed peptidoglycan is weakened from the absence of cross-linkages.