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Serious side effects may include heart disease, stroke, kidney problems, and stomach ulceration. [15] [9] Use is not recommended in the third trimester of pregnancy. [9] It is likely safe during breastfeeding. [15] Diclofenac is believed to work by decreasing the production of prostaglandins, like other drugs in this class. [16]
Meloxicam use can result in gastrointestinal toxicity and bleeding, headaches, rash, and very dark or black stool (a sign of intestinal bleeding). It has fewer gastrointestinal side effects than diclofenac, [17] piroxicam, [18] naproxen, [19] and perhaps all other NSAIDs which are not COX-2 selective.
Diclofenac sodium is an example of a non-steroidal anti-inflammatory drug used topically to reduce pain and inflammation. ... some active ingredients may cause more serious side effects, such as ...
Diclofenac [8] Ethosuximide [citation needed] Glutathione [9] Ibuprofen [10] Isotretinoin [11] Accutane Lamotrigine [12] Lamictal Modafinil [13] Provigil Nevirapine [citation needed] Norfloxacin [14] Oseltamivir [citation needed] Oxicams [7] Ampiroxicam, Piroxicam, Tenoxicam, Droxicam, Lornoxicam, Meloxicam, Isoxicam: Paracetamol [15] [16 ...
Indomethacin, ketoprofen, and piroxicam use appear to lead to the highest rate of gastric adverse effects, while ibuprofen (lower doses) and diclofenac appear to have lower rates. [ 17 ] Certain NSAIDs, such as aspirin, have been marketed in enteric-coated formulations that manufacturers claim reduce the incidence of gastrointestinal ADRs.
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A study confirmed that side effects like pancreatitis and kidney damage are possible while taking GLP-1s like Ozempic. Here's what a doctor wants you to know.
Topical analgesia is generally recommended to avoid systemic side-effects. Painful joints, for example, may be treated with an ibuprofen- or diclofenac-containing gel (The labeling for topical diclofenac has been updated to warn about drug-induced hepatotoxicity. [41]); capsaicin also is used topically.
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