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Hydrocodone is only pharmaceutically available as an oral medication. [2] It is well-absorbed, but the oral bioavailability of hydrocodone is only approximately 25%. [4] [5] The onset of action of hydrocodone via this route is 10 to 20 minutes, with a peak effect (T max) occurring at 30 to 60 minutes, [51] and it has a duration of 4 to 8 hours. [2]
In August 2014, the Drug Enforcement Administration (DEA) announced that all hydrocodone combination products (HCPs) would be rescheduled from schedule III to schedule II of the Controlled Substances Act (CSA), effective in October 2014. [11]
Bioequivalence studies have shown that benzhydrocodone/APAP is bioequivalent to other immediate-release hydrocodone combination products such as 7.5 mg hydrocodone/200 mg ibuprofen (Vicoprofen) and 7.5 mg hydrocodone/325 mg acetaminophen (Norco). [4] Benzhydrocodone is metabolized to hydrocodone by intestinal enzymes.
Norhydrocodone is the major metabolite of the opioid analgesic hydrocodone. [1] It is formed from hydrocodone in the liver via N-demethylation predominantly by CYP3A4. [1] Unlike hydromorphone, a minor metabolite of hydrocodone, norhydrocodone is described as inactive. [2]
Hydrocodone/ibuprofen , sold under the brand name Vicoprofen, is a fixed-dose combination analgesic medication used in short-term therapy to relieve severe pain. [ 3 ] [ 4 ] Vicoprofen combines the analgesic and antitussive properties of hydrocodone with the analgesic, anti-inflammatory, and antipyretic properties of ibuprofen . [ 1 ]
This page was last edited on 23 December 2023, at 08:42 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
Sam's Choice, originally introduced as Sam's American Choice in 1991, is a retail brand in food and selected hard goods. Named after Sam Walton, founder of Walmart, Sam's Choice forms the premium tier of Walmart's two-tiered core corporate grocery branding strategy that also includes the larger Great Value brand of discount-priced staple items.
Hydrocodone/aspirin is an oral combination drug formulation of the opioid analgesic hydrocodone and the nonsteroidal anti-inflammatory drug (NSAID) aspirin that is used in the treatment of chronic and acute pain.
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