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Cholera infections are most commonly acquired from drinking water in which V. cholerae is found naturally or into which it has been introduced from the feces of an infected person. Cholera is most likely to be found and spread in places with inadequate water treatment, poor sanitation, and inadequate hygiene.
Indian Council of Medical Research (ICMR) set up a cholera research centre at Kyd Street, Kolkata, West Bengal. [5] The aim of establishing this centre was to conduct research related to cholera and other enteric diseases. In 1979, the cholera research centre was renamed to National Institute of Cholera and Enteric Diseases (NICED).
Treatment of a cholera infection consists of replenishing lost fluid and electrolytes by intravenous or oral solutions, and by antibiotics. [2] El Tor outbreaks can be prevented by better standards of sanitation, filtering and boiling water, [ 4 ] thoroughly cooking seafood, and washing vegetables and fruits before consumption.
Cholera is caused by a number of types of Vibrio cholerae, with some types producing more severe disease than others. [2] It is spread mostly by unsafe water and unsafe food that has been contaminated with human feces containing the bacteria. [2] Undercooked shellfish is a common source. [9] Humans are the only known host for the bacteria. [2]
Vibrio vulnificus is a species of gram-negative, motile, curved rod-shaped (bacillus), pathogenic bacteria of the genus Vibrio.Present in marine environments such as estuaries, brackish ponds, or coastal areas, V. vulnificus is related to V. cholerae, the causative agent of cholera. [7]
Due to the polymicrobial etiology of P. multocida infections, treatment requires the use of antimicrobials targeted at the elimination of both aerobic and anaerobic, Gram-negative bacteria. As a result, amoxicillin-clavulanate (a beta-lactamase inhibitor/penicillin combination) is seen as the treatment of choice.
Vibrio cholerae bacteria are transmitted through contaminated water. [10] Once ingested, the bacteria colonize the intestinal tract of the host and produce a toxin which causes body fluids to flow across the lining of the intestine. Death can result in 2–3 hours from dehydration if no treatment is provided. [11]
Bacteria can reduce their susceptibility by changing their surface receptors and preventing phage adsorption. In the case of V. cholerae, the changed receptor gene expression is due to an alteration in cell-density during its infection cycle, a process called quorum sensing (QS). The stool samples collected from patients contain clumps of ...