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Meckel's cartilage is a piece of cartilage from which the mandibles (lower jaws) of vertebrates evolved. Originally it was the lower of two cartilages which supported the first branchial arch in early fish. Then it grew longer and stronger, and acquired muscles capable of closing the developing jaw. [1]
The mesenchymal cells within the mandibular prominence condense to form Meckel's cartilage. [2] ... hednk-032—Embryo Images at University of North Carolina
In humans and other vertebrates, the pharyngeal arches are derived from all three germ layers (the primary layers of cells that form during embryonic development). [2] Neural crest cells enter these arches where they contribute to features of the skull and facial skeleton such as bone and cartilage. [2]
Embryonic pharyngeal slits, which form in many animals when the thin branchial plates separating pharyngeal pouches and pharyngeal grooves perforate, open the pharynx to the outside. Pharyngeal arches appear in all tetrapod embryos: in mammals, the first pharyngeal arch develops into the lower jaw (Meckel's cartilage), the malleus and the stapes.
The face and neck development of the human embryo refers to the development of the structures from the third to eighth week that give rise to the future head and neck.They consist of three layers, the ectoderm, mesoderm and endoderm, which form the mesenchyme (derived form the lateral plate mesoderm and paraxial mesoderm), neural crest and neural placodes (from the ectoderm). [1]
Pattern of the pharyngeal arches.I-IV pharyngeal arches, 1-4 pharyngeal pouches (inside) and/or pharyngeal grooves (outside) a Lateral lingual swellings b Median tongue bud c Foramen cecum
These are ossified portions of cartilage—called Meckel's cartilage—that are attached to the jaw. As the embryo develops, the cartilage hardens to form bone. Later in development, the bone structure breaks loose from the jaw and migrates to the inner ear area.
In the embryonic development of vertebrates, pharyngeal pouches form on the endodermal side between the pharyngeal arches. The pharyngeal grooves (or clefts) form the lateral ectodermal surface of the neck region to separate the arches.