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Richter's transformation (RT), also known as Richter's syndrome, is the conversion of chronic lymphocytic leukemia (CLL) or its variant, small lymphocytic lymphoma (SLL), into a new and more aggressively malignant disease. [1] CLL is the circulation of malignant B lymphocytes with or without the infiltration of these cells into lymphatic or ...
Deaths. 60,700 (2015) [7] Chronic lymphocytic leukemia ( CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). [2] [8] Early on, there are typically no symptoms. [2] Later, non-painful lymph node swelling, feeling tired, fever, night sweats, or weight loss for no clear reason may occur.
B-cell CLL/lymphoma refers to a family of genes associated with certain types of lymphoma and leukemia . Although named for B-cell chronic lymphocytic leukemia, they can be associated with other malignancies. Members include: CCND1 (also known as "BCL1") BCL2. BCL3.
Aggressive NK-cell leukemia (ANKL) is a lymphoid leukemia that is a deficiency NK cells. Not very much is known about this disease due to its rarity, but it is highly aggressive. A majority of patients with NK cell leukemia die within a year of diagnosis, and for ANKL in particular, half of patients die within two months.
The symptoms of CKD in dogs are often subtle and can vary greatly depending on the stage of the disease. Initially, dogs may show no noticeable signs, but as the condition progresses, symptoms may ...
The B-cell lymphomas are types of lymphoma affecting B cells. Lymphomas are "blood cancers" in the lymph nodes. They develop more frequently in older adults and in immunocompromised individuals. B-cell lymphomas include both Hodgkin's lymphomas and most non-Hodgkin lymphomas. They are typically divided into low and high grade, typically ...
The presence of B symptoms is a marker for more advanced disease with systemic, rather than merely local, involvement. B symptoms are a clear negative prognostic factor in Hodgkin lymphoma. [2] The relevance of B symptoms in non-Hodgkin lymphoma is less clear, although B symptoms tend to correlate with disease that is either more widespread or ...
Signs and symptoms of chronic lymphocytic leukemia commonly precede those of multiple myeloma, sometimes by years. The relationship between the two clones of cells in this combined disease has not been established although one study suggests that the clonal plasma cells and clonal lymphocytes arise from a common hematological stem cell.